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Stem cells can effectively improve ovarian functio

09/03/23


Stem cell therapy works as a way to repair damaged tissue.Replace therapeutic method with Re-establish normal tissue function are also bringing new directions to a variety of intractable diseases, including premature ovarian failure.

The ovaries are the place where new life is born.However, some women are still of childbearing age, and premature ovarian failure leads to infertility and It's possible to lose fertility.

Premature ovarian failure (POF) is an incurable disease that causes ovarian failure before the age of 40 due to various reasons.

The diagnostic criteria for this disease are amenorrhea at least 4 months before the age of 40, blood FSH>40U/L2 times or more (more than 1 month between two tests), and estradiol 7.2pmol/L.The disease affects more than 1% of women of reproductive age.



干细胞治疗卵巢早衰,有效改善卵巢功能


In recent years, the trend is rising and getting younger. The two main threats of premature ovarian failure to female reproductive health are the decrease in estrogen levels and the loss of fertility.

Decreased estrogen levels increase a woman's risk of osteoporosis and coronary heart diseas. Women during the childbearing period have premature amenorrhea, loss of fertility, and are prone to depression, anxiety and other psychological problems.

Clinical manifestations of premature ovarian failure

1. Amenorrhea

There are primary amenorrhea and secondary amenorrhea, which occur before the age of 40. Through the investigation of a large sample of POF patients, it was found that there were no precursors of characteristic menstrual abnormalities before amenorrhea.

2. Infertility

Some patients are found to have premature ovarian failure due to infertility. Infertility is the main cause of treatment and distress in patients with premature ovarian failure.

3. Low estrogen symptoms

Dyspareunia, atrophic vaginitis, frequent urination, pain in urine and other atrophic urethritis.

4. Autoimmune diseases

Thyroid disease, diabetes, iupus erythematosus, arthritis deformans, vitiligo and crohn's disease.

5. Other symptoms

Weak physique, easy to catch cold. Physical strength decreased, mild activity fatigue obvious, irritability, dull skin, discoloration, dry skin, poor elasticity, increased wrinkles, osteoporosis. Joint pain, prone to fracture, bone decalcification.

With the development of stem cell research, a new therapeutic method has been provided for human understanding of the occurrence and development of diseases.

Stem cell therapy has made great progress in the field of basic research, and some of the research results have been applied to clinical trials of tumor diseases, autoimmune system diseases, nervous system diseases, cardiovascular diseases, and many clinical data have been obtained in clinical research, and many reports on clinical research and application of stem cells have been published.

How do stem cells treat premature ovarian failure?

1. Including secretion of a variety of cytokines, inhibit apoptosis, repair damaged tissue cells.

2. Colonize and differentiate the damaged part to partially compensate or replace its function.

3. Suppress the body's immune response and promote the self-repair of damaged tissues through immune regulation.

4. Repair ovarian interstitium to prevent ovarian fibrosis and protect damaged ovaries.

5. After entering the ovary, it can directly enter the damaged site and differentiate into some vascular endothelial cells to provide nutritional support;

6. It can change the expression of some genes and regulate ovarian function by changing genes.

Stem cell therapy for premature ovarian failure

It was the worst of times and the living conditions were getting worse and worse. But it is also the best of times: the discovery of stem cells and the application of stem cell therapy have improved the quality of human life.

1. Intravenous cell infusion.

2. Ovarian artery and uterine artery cells were injected.

3. Direct ovarian cell injection by laparoscope.

The effect of stem cell therapy on premature ovarian failure

1. Recovery of ovarian function, recovery of ovulation, There are many people who conceive normally, and even if they cannot conceive normally, it lays the foundation for the success of IVF.

2. Good health and physical recovery, increased endurance, sensitive senses.

3. Skin is pale and smooth, firm and moist, dark spots disappear, reduced wrinkles.

4. Relieve irritability, insomnia and dreams, dry heat and sweat, lack of appetite.

A typical case

Female, 47 years old, She has no history of fertility and has had regular menstruation in the past, and hopes to successfully retrieve eggs through stem cell therapy to prepare for IVF. The patient used to receive ovulation induction therapy, traditional Chinese medicine, acupuncture and other treatments. But the effect is not good, no active follicles, two IVF surgery failed.

Before treatment

The patient had shown decreased ovarian function prior to stem cell therapy:

1. Decreased physical strength and increased fatigue after light activities.

2. Decreased sensitivity of body senses, such as eyes, ears, nose, etc.

3. Severe osteoporosis, waist and leg pain.

4. Dry and dull skin, spots, wrinkles increased.

5. Five upset hot, irritable

6. Six kinds of serum hormones indicated that increased luteinizing hormone and follicle-stimulating hormone. Low AMH value.

7. B-ultrasound showed no follicular shadow in the right ovary.

After treatment

After routine examination, there were no significant abnormalities in stem cell therapy. After the treatment, the patient changed a lot, the egg retrieval was successful, and the IVF surgery was successful. Other postoperative changes are as follows:

1. Physical strength, fitness do not feel tired;

2. Be able to see and hear well.

3. Relieve back and leg pain.

4. Fair and elastic skin, wrinkles are reduced, spots disappear.

5. Be calm.

6. Six kinds of serum hormones indicated that luteinizing hormone and follicle-stimulating hormone decreased. AMH value increased.

7. B-ultrasound showed follicular shadow in the right ovary.